Product Name: N,N-Dimethylformamide
Chemical Formula: C3H7NO
CAS Number: 68-12-2
Synonyms: DMF, Dimethylformamide
Manufacturer: Refer to supplier's section for details specific to organization
Recommended Use: Used as a solvent in chemical reactions, textile production, and pharmaceuticals
Emergency Contact: Refer to local emergency services or poison control
GHS Classification: Flammable liquid (Category 3), Acute toxicity - Oral (Category 4), Skin irritation (Category 2), Eye irritation (Category 2A), Specific target organ toxicity - single exposure (Category 3), Reproductive toxicity (Category 1B)
Pictograms: Flame, Exclamation mark, Health hazard
Signal Word: Danger
Hazard Statements: Causes serious eye irritation, may damage fertility or unborn child, harmful if swallowed, toxic if inhaled or absorbed through skin, can cause nausea, headache, or drowsiness, flammable liquid and vapor
Precautionary Statements: Avoid all contact with skin and eyes, do not eat or drink while using, keep away from ignition sources
Chemical Name: N,N-Dimethylformamide
Concentration: 99-100%
CAS Number: 68-12-2
Impurities: Trace levels of water or decomposition products possible
Inhalation: Move person to fresh air immediately, keep at rest in a position comfortable for breathing, get medical attention if symptoms persist
Skin Contact: Remove contaminated clothing, wash skin thoroughly with soap and water, seek medical advice if irritation occurs
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing, seek medical attention if irritation develops
Ingestion: Do not induce vomiting, rinse mouth, drink water if conscious, call for medical assistance without delay
Most Important Symptoms: Eye and skin irritation, headaches, dizziness, fatigue, potential liver or kidney effects with prolonged or repeated exposure
Special Treatment: Provide symptomatic support, monitor vital signs, doctors may need to check liver and kidney function in severe cases
Suitable Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide
Unsuitable Media: Do not use high-pressure water streams directly on the liquid
Special Hazards: Vapors may form explosive mixtures with air, combustion generates toxic gases (carbon monoxide, nitrogen oxides)
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective clothing
Advice for Firefighters: Isolate area, cool containers exposed to flames with water spray, avoid inhaling fumes
Personal Precautions: Evacuate area if necessary, ventilate environment, use personal protective equipment such as gloves, goggles, respirators
Environmental Precautions: Prevent further leakage or spillage if safe to do, do not let product enter drains, soil, or watercourses
Methods for Cleanup: Absorb spills with inert materials (sand, earth, vermiculite), collect into properly labeled containers for disposal, wash contaminated area with plenty of water, use nonsparking tools
Handling: Handle in well-ventilated places, avoid inhalation or skin contact, keep containers tightly closed, use proper grounding and bonding when transferring liquids, keep away from sources of ignition
Storage: Store in cool, dry, well-ventilated locations, keep containers tightly sealed when not in use, keep away from oxidizers, acids, and moisture, protect from direct sunlight
Incompatible Materials: Avoid strong acids, strong bases, oxidizing agents, halogens, and moisture-reactive chemicals
Exposure Limits: OSHA PEL: 10 ppm (TWA); ACGIH TLV: 10 ppm (TWA)
Engineering Controls: Use local exhaust ventilation to reduce vapor concentrations, splash guards and eye-wash stations recommended
Personal Protective Equipment: Chemical-resistant gloves (nitrile recommended), safety goggles or face shield, flame-resistant lab coat or coveralls, appropriate respiratory protection if airborne concentrations exceed limits
Hygiene Measures: Wash hands thoroughly after handling, no eating, drinking, or smoking in work area, remove and wash contaminated clothing before reuse
Appearance: Clear, colorless to slightly yellow liquid
Odor: Faint, fishy
Melting Point: -61°C (-78°F)
Boiling Point: 153°C (307°F)
Flash Point: 58°C (136°F) (closed cup)
Flammability: Flammable liquid and vapor
Vapor Pressure: 2.7 mmHg at 20°C (68°F)
Solubility: Miscible with water and most organic solvents
Density: 0.944 g/cm³ at 20°C
Viscosity: 0.92 mPa·s at 20°C
Partition Coefficient: log Kow -1.01
Evaporation Rate: 0.5 (butyl acetate = 1)
Chemical Stability: Stable under recommended handling and storage conditions
Hazardous Reactions: Reacts with strong oxidizers, acids, and bases releasing heat and hazardous byproducts
Hazardous Decomposition Products: Emits toxic fumes including carbon monoxide, carbon dioxide, nitrogen oxides, dimethylamine on thermal decomposition
Conditions to Avoid: Heat, sparks, open flames, static electricity, incompatible materials
Acute Toxicity: Oral LD50 (rat): 2800 mg/kg, Dermal LD50 (rabbit): 1500 mg/kg, Inhalation LC50 (rat, 4hr): 9400 mg/m³
Routes of Exposure: Inhalation, skin and eye contact, ingestion
Symptoms: Irritation of eyes, skin, and respiratory tract, nausea, headache, dizziness, potential liver, and kidney effects with chronic or high-level exposure
Sensitization: No evidence found for skin or respiratory sensitization
Carcinogenicity: Not classified as carcinogenic by IARC, ACGIH, NTP, or OSHA at this time
Reproductive Toxicity: Evidence suggests risk to fertility or unborn children in laboratory studies
Aquatic Toxicity: Toxic to aquatic organisms at high concentrations; Fish LC50 (96h): 7100 mg/L (Lepomis macrochirus)
Persistence and Degradability: Biodegradable under aerobic conditions
Bioaccumulation Potential: Low (log Kow -1.01)
Mobility in Soil: High, moves easily through soils and leaches into groundwater
Other Adverse Effects: Avoid release to the environment, significant spills can affect water quality
Disposal Methods: Collect and dispose of in accordance with local, regional, and national regulations for hazardous waste
Contaminated Packaging: Triply rinse containers before disposal, remove all labeling, dispose as hazardous waste
Special Instructions: Never discharge into sewers or municipal water supplies, professional disposal is strongly recommended
UN Number: UN2265
Proper Shipping Name: N,N-Dimethylformamide
Transport Hazard Class: 3 (Flammable liquids)
Packing Group: III
Environmental Hazards: Not classified as marine pollutant
Special Precautions: Ensure packaging prevents leaks and vapor release, avoid shipment with incompatible substances, refer to regulations for precise packing instructions
OSHA: Listed hazardous chemical, requires communication of hazards in workplace safety programs
SARA Title III: Section 313 toxic chemical (reportable if above threshold limits)
TSCA: Listed on U.S. TSCA inventory
REACH Registration: Registered under EC 1907/2006
California Proposition 65: Listed as reproductive toxicant
WHMIS: Classified as D1B (Toxic Material Causing Immediate and Serious Toxic Effects), D2A (Very Toxic Material Causing Other Toxic Effects), B2 (Flammable Liquid)
Other Listings: Check national, regional, and industry-specific regulations for compliance in transport, storage, and use
