It can dissolve some low-solubility pigments and make the pigments have the characteristics of dyes. N,N-Dimethylformamide can also be used as an effective reagent for separating non-hydrocarbon components from paraffin wax. It has good selectivity for the solubility of terephthalic acid and isophthalic acid, the solubility of isophthalic acid in N,N-dimethylformamide is greater than that of terephthalic acid. They can be isolated by solvent extraction or partial crystallization in N,N-dimethylformamide. N,N-dimethylformamide is also an important solvent and reagent in organic synthesis.

N,N-dimethylformamide is a good aprotic polar solvent, which can dissolve most organic and inorganic substances, and is miscible with water, alcohol, ether, aldehyde, ketone, ester, halogenated hydrocarbon and aromatic hydrocarbon, etc.
The positively charged end of the N,N-dimethylformamide molecule is surrounded by methyl groups, forming a steric barrier that prevents negative ions from accessing and only associates with positive ions. Naked anions are much more active than solvated anions.
Many ionic reactions are easier to carry out in N,N-dimethylformamide than in general protic solvents, such as the reaction of carboxylate and halogenated hydrocarbons in N,N-dimethylformamide at room temperature, It can generate high-yield esters and is especially suitable for the synthesis of sterically hindered esters.
N,N-Dimethylformamide can be prepared by reacting formamide with dimethylamine, or by reacting a solution of dimethylamine in methanol with carbon monoxide in the presence of sodium alkoxide. N,N-dimethylformamide has good solvent properties for various high polymers such as polyethylene, polyvinyl chloride, polyacrylonitrile, polyamide, etc., and is widely used in plastic film, paint, fiber and other industries; It can also be used as a paint remover for removing paint.